Principal Investigator:

Mark Laubach, PhD
Associate Fellow,
John B. Pierce Laboratory

Assistant Professor of Neurobiology
Yale University School of Medicine


Research Interests

The long-term goal of the Laubach Lab is to understand the role of the frontal cortex and the basal ganglia in the flexible control of behavior. Our current focus is on understanding how cortical and striatal networks are able to anticipate stimuli that have reward value, maintain information about such stimuli in working memory, and undergo changes in activity during learning. These issues are studied using multi-electrode recording methods in awake, behaving rodents. We are also actively studying how information can be decoded from spike activity and relations between spike trains and field potentials. Our research is supported by the National Science Foundation, the National Institute of Health, and the Kavli Foundation. We are a core group in the Swartz Initiative for Theoretical and Systems Neuroscience at Yale
(http://swartz-initiative.med.yale.edu/).


Top-Down Control of Action by
Medial Frontal Cortex

Recent Publications

Laubach M., Narayanan NS, and Kimchi EY. "Single-neuron and ensemble contributions to decoding simultaneously recorded spike trains." Chapter 6 in "Mechanisms of Information Processing in the Brain", Edited by Christian Hölscher and Matthias Munk. Cambridge University Press. In Press.
Expected to be available at SfN-07 in San Diego.

Narayanan NS, Laubach M. "Top-down control of motor cortex ensembles by dorsomedial prefrontal cortex." Neuron. 2006 52:921-931.
http://spikelab.jbpierce.org/Publications/Narayanan-Laubach-Neuron-2006.pdf

Narayanan NS, Horst NK, Laubach M. "Reversible inactivations of rat medial prefrontal cortex impair the ability to wait for a stimulus." Neuroscience. 2006 139:865-76.
http://spikelab.jbpierce.org/Publications/Narayanan-Neuroscience-2006.pdf

Laubach M. "Who's on first? What's on second? The time course of learning in corticostriatal systems." Trends in Neuroscience. 2005 28:509-11.
http://spikelab.jbpierce.org/Publications/LaubachTINS2005.pdf

Narayanan NS, Kimchi EY, Laubach M. "Redundancy and synergy of neuronal ensembles in motor cortex." J Neuroscience. 2005 April 27;25(17):4207-4216.
http://spikelab.jbpierce.org/Publications/NarayananJNeurosci2005.pdf


Mark Laubach, PhD
Principal Investigator
Nicole Horst, BS
Yale Graduate Student
Eyal Kimchi, BS
Yale Graduate Student
Kumar Narayanan, BS
Yale Graduate Student