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Principal Investigator:

Mark Laubach, PhD
Associate Fellow,
John B. Pierce Laboratory

Assistant Professor of Neurobiology
Yale University School of Medicine


Research Interests

The long-term goal of the Laubach Lab is to understand the role of the frontal cortex and the basal ganglia in goal-directed behavior.
Currently, we are carrying out three lines of research on the neuronal basis of behavioral strategies that enable effective food-seeking behavior, or foraging. First, we are studying how we anticipate food-predictive stimuli and control our actions to optimize food collection. Second, we are studying how we learn the values of stimuli in the environment and flexibly track stimulus value under changing environmental circumstances. Third, we are studying how working memory is used to link together sequences of actions that lead to the collection of food. To study these issues, we use multi-electrode recording methods in awake, behaving rodents. We also use reversible inactivations, local drug infusions, and tract-tracing methods and are active in developing methods for quantifying how neuronal spike trains and population activity represent information about behavior and how spike trains relate to ongoing oscillations of local field potentials.

Our research is supported by the National Science Foundation and the National Institute of Health and we are a core group in the Swartz Initiative for Theoretical and Systems Neuroscience at Yale.


Top-Down Control of Action by
Medial Frontal Cortex

Recent Publications

Laubach M., Narayanan NS, and Kimchi EY. "Single-neuron and ensemble contributions to decoding simultaneously recorded spike trains." Chapter 6 in "Mechanisms of Information Processing in the Brain", Edited by Christian Hölscher and Matthias Munk. Cambridge University Press. In Press.
Expected to be available at SfN-07 in San Diego.

Narayanan NS, Laubach M. "Top-down control of motor cortex ensembles by dorsomedial prefrontal cortex." Neuron. 2006 52:921-931.
http://spikelab.jbpierce.org/Publications/Narayanan-Laubach-Neuron-2006.pdf

Narayanan NS, Horst NK, Laubach M. "Reversible inactivations of rat medial prefrontal cortex impair the ability to wait for a stimulus." Neuroscience. 2006 139:865-76.
http://spikelab.jbpierce.org/Publications/Narayanan-Neuroscience-2006.pdf

Laubach M. "Who's on first? What's on second? The time course of learning in corticostriatal systems." Trends in Neuroscience. 2005 28:509-11.
http://spikelab.jbpierce.org/Publications/LaubachTINS2005.pdf

Narayanan NS, Kimchi EY, Laubach M. "Redundancy and synergy of neuronal ensembles in motor cortex." J Neuroscience. 2005 April 27;25(17):4207-4216.
http://spikelab.jbpierce.org/Publications/NarayananJNeurosci2005.pdf


Mark Laubach, PhD
Principal Investigator
Nicole Horst, BS
Yale Graduate Student
Eyal Kimchi, BS
Yale Graduate Student
NATE
Nate Smith, BS
Yale Graduate Student